منابع مشابه
Atopic dermatitis phenotypes in childhood
BACKGROUND Atopic dermatitis (AD) is a chronic inflammatory skin disease and can be the first step of the atopic march. OBJECTIVE In this retrospective study, we analysed the immunological and clinical patterns of AD in a group of children affected by the disease since their first years of life, in order to evaluate if and how these patterns can change over time, and to identify biomarkers th...
متن کاملClinical Management of Atopic Dermatitis
Atopic Dermatitis (AD) is a common inflammatory, pruritic skin disorder. It is a chronic disease with often relapse. Several factors including genetic predisposition, allergies to specific foods, irritant chemicals, and aeroallergens are thought to be the cause of AD. Diagnosis is difficult, and often occurs after ruling out other disorders with a clinical presentation resembling atopic dermati...
متن کاملAtopic dermatitis. A clinical challenge.
Atopic dermatitis has a significant impact on both the pediatric and adult population worldwide, which has triggered extensive research on the topic. However, various limitations have created difficulties both in making accurate diagnoses and effectively managing atopic dermatitis patients. This review summarizes the current knowledge in the field, providing an overview of the pathophysiology, ...
متن کاملAssociation of FLG single nucleotide variations with clinical phenotypes of atopic dermatitis
BACKGROUND FLG encodes a large protein called profilaggrin, which plays a key role in maintaining an effective skin barrier against the environment. In this study, we identified FLG single nucleotide variations (FLG-SNVs) and evaluated the association of FLG-SNVs with clinical phenotypes including atopic dermatitis (AD)-associated minor clinical features, presence of specific allergic sensitiza...
متن کاملPathogenesis of Atopic Dermatitis: Current Paradigm
Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. In this review, recent advances in the pathogenesis of AD are summarized. Clinical efficacy of the anti-IL-4 receptor antibody dupilumab implies that type 2 cytokines IL-4 and IL-13 have pivotal roles in atopic inflammation. The expression of IL-4 and IL-13 as well as type 2 chemokines such a...
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ژورنال
عنوان ژورنال: Dermatology Review
سال: 2018
ISSN: 0033-2526
DOI: 10.5114/dr.2018.75583